The following events in the history of Missouri that affected political boundaries and movements of the population.
- 1735: French lead miners established the first permanent white settlement at Sainte Genevieve.
- 1763: France ceded the Missouri area to Spain. French fur traders founded St. Louis in 1764.
- 1800: Spain returned the region to France.
- 1803: France sold Missouri to the United States as part of the Louisiana Purchase. Missouri was part of the Louisiana Territory after 1805.
- 1812: (June 4,) Congress created the Missouri Territory. Major earthquakes and other disasters forced many families out of the region.
- 1821: (August 10,) Missouri became a state.
- 1837: The Osage Indians ceded land.
- 1837: The Platte Purchase added six northwestern counties to the state.
Oregon Trail and Santa Fe Trail start at Independence, Missouri
- 1861-1865: During the Civil War most of the citizens supported the Union, although several counties seceded. Troops from Missouri served in both the Confederate and the Union forces.
- 1898: Over 300,000 men were involved in the Spanish-American War which was fought mainly in Cuba and the Philippines.
- 1917–1918: More than 26 million men from the United States ages 18 through 45 registered with the Selective Service. World War I over 4.7 million American men and women served during the war.
- 1930's: The Great Depression closed many factories and mills. Many small farms were abandoned, and many families moved to cities.
- 1940–1945: Over 50.6 million men ages 18 to 65 registered with the Selective Service. Over 16.3 million American men and women served in the armed forces during World War II.
- 1950–1953: Over 5.7 million American men and women served in the Korean War.
- 1950's–1960's The building of interstate highways made it easier for people to move long distances.
- 1964–1972: Over 8.7 million American men and women served in the Vietnam War.
Timeline courtesy of FamilySearch.org